Basal Ganglia Mineralization in Schizophrenia
نویسنده
چکیده
We presented an abnormal second messeng'~r mechanism in platelet signal transduction in schizophrenic patients. As Drs. Tandon and Greden considered, the abnormality may be caused by a malfunction of neurotransmitters corresponding to the second messenger system (i.e., acetylcholine). Another possibility is that the abnormality may exist in the second messenger metabolism itself. We are of the latter opinion and presented a platelet phospholipid model for the pathogenesis of schizophrenia (Kaiya 1990). In this hypothesis, the pathogenesis is thought to be a systemic metabolic disorder related to a disturbance in essential fatty acid, excess in prostaglandin E2, deficiency in prostaglandin El, decrease in cAMP formation, increase in diacylglycerol, increase in phospholipase A2, and increase in free arac~donic acid, all of which were demonstrated in schizophrenic platelets or plasma.
منابع مشابه
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